Ocular motility as a measure of cerebral dysfunction in adults with focal epilepsy

HM Au Yong; M Clough; P Perucca; CB Malpas; P Kwan; TJ O'Brien; J Fielding

Journal article

Ocular motility as a measure of cerebral dysfunction in adults with focal epilepsy

HM Au Yong, M Clough, P Perucca, CB Malpas, P Kwan, TJ O'Brien, J Fielding

Epilepsy and Behavior | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2023

DOI: 10.1016/j.yebeh.2023.109140

Abstract

Objective: Using objective oculomotor measures, we aimed to: (1) compare oculomotor performance in patients with drug-resistant focal epilepsy to healthy controls, and (2) investigate the differential impact of epileptogenic focus laterality and location on oculomotor performance. Methods: We recruited 51 adults with drug-resistant focal epilepsy from the Comprehensive Epilepsy Programs of two tertiary hospitals and 31 healthy controls to perform prosaccade and antisaccade tasks. Oculomotor variables of interest were latency, visuospatial accuracy, and antisaccade error rate. Linear mixed models were performed to compare interactions between groups (epilepsy, control) and oculomotor tasks, a..

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University of Melbourne Researchers

Piero Perucca Author

Charles Malpas Author

Patrick Kwan Author

Related Projects (1)

INVESTIGATING THE GENETIC CONTRIBUTION TO THE FOCAL EPILEPSIES

Focal epilepsies are the most common forms of epilepsy. In most people with these epilepsies, no cause for the seizures can be identified wi..

Grants

Awarded by Australian Government

Funding Acknowledgements

HMAY was supported by the Research Training Program (RTP) Scholarship provided by the Australian Government. PP is supported by the National Health and Medical Research Council (APP1163708), the Epilepsy Foundation, The University of Melbourne, Monash University, The Norman Beischer Medical Research Foundation, Brain Australia, and the Weary Dunlop Medical Research Foundation. PK was supported by a Medical Research Future Fund Practitioner Fellowship (MRF1136427). TJO was supported by an NHMRC Investigator Grant (APP1176426).